Toy Story 3 é um filme de animação americano de 2010, dos gêneros aventura e comédia, dirigido por Lee Unkrich, responsável pela edição dos dois primeiros filmes e pela co-direção de Toy Story 2, e roteirizado por Michael Arndt. [6] Produzido pela Pixar Animation Studios, distribuído pela Walt Disney Studios Motion Pictures e lançado em 3D, é a sequência de Toy Story 2 (1999), e ...

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INTRODUCTION. Sirtuins are histone nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases widely recognized for their link to eukaryotic life span (Guarente and Picard, 2005; Michan and Sinclair, 2007).Silent information regulator 1 (SIRT1), the most studied among the seven mammalian sirtuins, increases when situations favor longevity, such as caloric restriction or following ...

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Music composed by Tom Doyle. DADS! The Musical is an uproariously funny but poignant look at role reversal and the contemporary male, performed by three men and one woman – and one keyboard player – plus four babies (puppets). It features lovable characters, hilarious scenes and 13 high-energy musical numbers.Suddenly

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Sirtuins (Sir2-related enzymes) are a recently discovered class of NAD+-dependent protein deacetylases that regulate gene expression in a variety of organisms by deacetylation of modified lysine residues on histones, transcription factors and other proteins. Conservation of sirtuin regulation of the insulin–insulin-like growth factor I signaling pathway has been observed for Caenorhabditis ...

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